Fat-Soluble Vitamins in Wound Healing

Function in Wound Vitamin Healing

A Major role in the differentiation and function of epithelial tissue; cofactor for collagen synthesis and cross-linkage; required for synthesis of glycoproteins and proteoglycans; stimulates fibroplasia and normalizes keritinization; inflammatory response is dependent on the presence of adequate vitamin A; counteracts the deleterious effects of glucocorticoids on cell membranes

Subjects at Risk of Deficiency [Reference]

Malnutrition, injury, burns [144-147], chronic wounds [148]


Vitamin A as retinol is found in animal products; good sources include liver, fish liver oils, enriched dairy products, and egg yolk; beta-carotene is found in plants, including yellow and orange fruits and vegetables such as carrots, sweet potato, squash, winter squash, dried apricots, peaches, and dark green leafy vegetables including spinach, broccoli, and lettuce til hO

Dietary Reference Intakes (DRI)



Males: 9-13 yr, 2000 IU/d; 14-18 yr, 3000 IU/d; 19-30 yr, 3000 IU/d; 31-50 yr, 3000 IU/d; 50-70 yr, 3000 IU/d;

9-13 yr, 2000 IU/d; 14-18 yr, 2333 IU/d; 19-30 yr, 2333 IU/d; 31-50 yr, 2333 IU/d; 50-70 yr, 2333 IU/d;

< 18 yr, 2500 IU/d; 19-30 yr, 2566 IU/d; 31-50 yr, 2566 IU/d


< 18 yr, 4000 IU/d; 19-30 yr, 4333 IU/d; 31-50 yr, 4333 IU/d

Recommendations to Optimize Wound Healing [Reference]

Correct deficiency; daily enteric supplementation of 10,000-25,000 IU may enhance wound healing in patients with poor nutrient stores, malabsorption, severe injury or in those receiving steroids [16,37,39,46^18]

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