Table 146

Other Metabolic Effects of Human Growth Hormone

Increases hydrolysis of fat to fatty acids Increases fat oxidation for fuel, decreasing fat stores Increases metabolic rate (10 to 15%)

Produces insulin resistance, often leading to hyperglycemia Causes some initial fluid retention

Results of Exogenous hgh Use

Clinical studies have in large part focused on the systemic anabolic and anticat-abolic actions of HGH.52-54 Populations in which HGH has been shown to be beneficial include severe burn and trauma, HIV infection with wasting, and frail elderly adults (Table 14.7). In addition, HGH is being used to decrease the aging process. Increases in lean mass, muscle strength, and immune function have been documented in clinical use. HGH is approved only for use in children of short stature and is an orphan drug when used for improving protein synthesis. Increased anabolic activity requires implementation of a high-protein, high-energy diet.

Wound Healing Effect

As to its direct wound healing effects, skin is a target tissue for HGH, both directly through HGH receptors on the surface of epidermal cells and indirectly through the action of insulin-like growth factor IGF-1.52-53 Exogenously administered HGH has been shown to increase skin thickness in normal humans.46 Other effects on the wound include increased rate of re-epithelialization of skin graft donor sites in adults and children with severe burns or trauma55-57 (Table 14.8). In addition, HGH has been shown to increase wound collagen content, granulation tissue and wound tensile strength, and the local production of IGF-1 by fibroblasts. These data are derived mainly from animal studies.55-57

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Metabolism. There isn’t perhaps a more frequently used word in the weight loss (and weight gain) vocabulary than this. Indeed, it’s not uncommon to overhear people talking about their struggles or triumphs over the holiday bulge or love handles in terms of whether their metabolism is working, or not.

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