FIGURE 8.5 Lipid peroxidation in cell membrane. By reaction with polyunsaturated fatty acids in the cell membranes, more stable lipid peroxides are generated, which may exert their damage at a distance from the original site. Furthermore, polyunsaturated fatty acids and their phospholipid esters are readily oxidized by a chain reaction mechanism. Once an initiating lipid radical is generated, it attacks another lipid to form a second lipid radical; thus, this lipid peroxidation cycle is propagated. (See also Niki, E. et al., J. Biol. Chem., 259, 4177, 1984.) The final stable substance, malondialdehyde (MDA) is often used as a way to study free radical metabolism. (L = lipid.) (From Niki, E., Ann. N.Y. Acad. Sci, 498: 186, 1987. With permission.)

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