Hideharu Tanaka and Joseph A Molnar

contents

Background 121

Ascorbic Acid Deficiency 122

Biochemical Functions of Ascorbic Acid 123

Vitamin C as an Enzymatic Cofactor 123

Vitamin C as a Free Radical Scavenger 126

Ascorbic Acid Requirements 129

Wound Healing and Ascorbic Acid as an Enzymatic Cofactor 132

Clinical Application of Vitamin C as a Free Radical Scavenger 134

Lung Injury and ARDS (Adult Respiratory Distress Syndrome) 135

Paraquat Intoxication 136

Brain Injury 136

Ischemia-Reperfusion Injury 136

Thermal Injury and Oxygen Radicals 136

Laboratory Studies of Vitamin C and Burn Injury 138

Clinical Studies of Vitamin C and Burn Injury 138

Toxicity of Vitamin C 141

Recommendations for Vitamin C to Support Wound Healing 143

Future Directions 143

References 144

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