Cytokine response to trauma and surgery

Thrombocytosis that occurs during the first hours after tissue injury aids in hemostasis, and platelets release many growth factors, such as transforming growth factor beta (TGF-ß) and insulin-like growth factor (IGF-1), which regulate inflammation, immune response, and cell migration. In the inflammatory phase, the local effects of inflammation can be amplified to a systemic level due to production of cytokines, such as tumor necrosis factor (TNF), interferon-y, interleukin-1 (IL-1), IL-6, IL-8, and IL-12 associated with a Th1 proinflammatory pathway, or cytokines with anti-inflammatory type 2 helper cell (Th2), including IL-4 and IL-10, which may contribute to the immunosuppression in sepsis and burns (Table 11.1). Thus critically ill patients have a biphasic immunological response. An initial excessive systemic inflammatory response syndrome (SIRS) with increased TNF, IL-1, and IL-10, interferon (IFN)-y or an inadequate compensatory anti-inflammatory response syndrome (CARS) is

Metabolism Masterclass

Metabolism Masterclass

Are You Sick And Tired Of All The Fat-Burning Tricks And Trends That Just Don’t Deliver? Well, Get Set To Discover The Easy, Safe, Fast, And Permanent Way To Mega-Charge Your Metabolism And Lose Excess Fat Once And For All! This Weight Blasting Method Is Easy AND Natural… And Will Give You The Hot Body And Killer Energy Levels You’ve Been Dreaming Of.

Get My Free Ebook


Post a comment