Figure 122

Acquisition of win-shift 8-Arm radial maze performance by mice.31

baited to unbaited. Although some investigators test working and reference memory on an 8-arm maze with four baited and four unbaited arms, this lessens the sensitivity of the task as the memory demands for the location of four baits is low. We have found that use of a 16-arm maze with 12 baited and 4 unbaited arms provides a useful measure of working vs. reference memory while keeping task demands high. Figure 12.3 shows an example of working and reference memory performance on a 16-arm radial maze with the muscarinic antagonist scopolamine causing a selective impairment in working memory performance.

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