Delayed Alternation Tasks

The spatial delayed alternation task (DA) is another task that involves short-term working memory and requires animals to alternate their responding between two spatially distinct locations. Like the DMTP task, it is very sensitive to damage of the mPFC. Indeed, deficits in delayed alternation in Wisconsin boxes (for monkeys) and in T mazes (for rats) were among the defining features of the prefrontal deficit described by Jacobsen in his classic primate studies in the 1930s,89,90 and replicated many times since.21,91,92 Rats similarly exhibit clear deficits in delayed alternation after prefrontal lesions when tested in a T maze.88,93-95

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