Aminophylline and Theophylline secondline therapy

-Aminophylline load dose: 5.6 mg/kg total body weight in 100 mL D5W IV over 20min. Maintenance of 0.5-0.6 mg/kg ideal body weight/h (500 mg in 250 mL D5W); reduce if elderly, heart/liver failure (0.2-0.4 mg/kg/hr). Reduce load 50-75% if taking theophylline (1 mg/kg of aminophylline will raise levels 2 mcg/mL) OR -Theophylline IV solution loading dose 4.5 mg/kg total body weight, then 0.40.5 mg/kg ideal body weight/hr. -Theophylline (Theo-Dur) PO loading dose of 6 mg/kg, then maintenance of 100-400 mg PO bid-tid (3 mg/kg q8h); 80% of total daily IV aminophylline in 2-3 doses.

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