Rheumatologic or inflammatory disorders

4. Malignant disorders. These include leukemias (acute lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia), myeloproliferative disorders, or solid tumors infiltrating the marrow.

5. Leukemoid reaction. Infants with Down syndrome can develop a transient leukemoid reaction with extremely high WBC count, consisting mostly of neutrophils and immature myeloid elements, which resolves spontaneously. Blood smear can resemble that seen in chronic myelogenous leukemia.

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