Sicherer SH. How to recognize and manage anaphylaxis. J Res Dis Pediatr 2003;5:191-198.

Uram R. What every pediatrician must know about anaphylaxis and anaphylactoid reactions. Pediatr Ann 2000;29:737-742. Wyatt R. Anaphylaxis. How to recognize, treat and prevent potentially fatal attacks. Postgrad Med 1996;100:87-90, 96-99.

Other considerations

• Ranitidine, 1 mg/kg IV q6h for persistent anaphylaxis

• Glucagon, 0.05-1 mg IV in over 5 min, followed by infusion (0.1 mg/kg/hr) titrated to clinical response, for anaphylaxis resistant to epinephrine, specifically in patients receiving ß-blocking agents and ACE inhibitors

Figure I-2. General approach to management of anaphylaxis. (ACE = angiotensin-converting enzyme; ET = endotracheal; NS = normal saline; PICU = pediatric intensive care unit.)

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