Jansen syndrome

B. Childhood Hypercalcemia

1. Immobilization. Commonly seen in adolescents weeks after severe trauma.

2. Malignancy. Can occur with solid tumors, lymphoma, and leukemia.

3. Granulomatous diseases. Sarcoidosis, tuberculosis, cat-scratch disease. Increased formation of 1,25-dihydroxyvitamin D.

4. Medications. Similar to those listed for infants, earlier.

5. Hyperparathyroidism. Often familial.

6. Familial hypocalciuric hypercalcemia (FHH). Heterozygous form is benign and associated with low excretion of calcium and magnesium.

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