Other Causes

1. Idiopathic neonatal hepatitis. Also known as giant cell hepatitis. Second most common "diagnosis" in neonatal cholestasis, after biliary atresia. However, with improved ability to diagnose some metabolic and genetic disorders, the number of patients who fall into this category has been decreasing over the past 10-20 years. In general, presentation of infants with this condition is similar to that of infants with biliary atresia (ie, acholic stools and jaundice by 3 months of age). There is a slight male preponderance, and 10-20% of cases are familial (these patients have a worse clinical outcome).

3. Histiocytosis X.

4. Neonatal lupus.

5. Extracorporeal membrane oxygenation.

6. Graft-versus-host disease.

7. Venoocclusive disease.

8. Autosomal trisomies.

9. Erythroblastosis fetalis.

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