C. Drugs. Side effects of common over-the-counter medications (OTC) and prescription drugs may result in excessive crying. Includes antihistamines, OTC cough preparations, pseu-doephedrine, phenobarbital, and corticosteroids. Also consider ethanol withdrawal and neonatal narcotic withdrawal.

D. Colic. Etiology is unclear. Occurs in 10-25% of otherwise healthy and well-nourished infants. Defined as paroxysmal crying beginning in the first 3 weeks of life, lasting longer than 3 hours a day, at least 3 days per week, and continuing for more than 3 weeks in infants younger than 3 months old ("rule of 3's"). Crying is qualitatively normal, but quantitatively excessive. Generally worse in evening. Infants may be inconsolable, with facial flushing, grimacing, clenched fists, flatulence, or drawing up of legs during episodes.

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