Physical Exam Key Points

1. Vital signs. Fever raises concerns of infection, leukemia, and ITP.

2. Skin and mucous membranes. Petechiae and mucous membrane bleeding suggest low platelet number or abnormal platelet function, or both.

3. Lymph nodes. Enlarged nodes suggest infection or malignancy.

4. Abdomen. Enlargement of liver or spleen, or both, can suggest malignancy (leukemia), but splenomegaly can also be seen with hypersplenism, storage diseases, or infection.

5. Neurologic exam. Abnormal findings raise concerns regarding TTP.

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