Systemic Manifestations

Systemic manifestations reported in 30 patients with congenital HSV include low birth weight, small for gestational age, microcephaly, seizures, diffuse brain damage, intracranial calcifications, scars on skin or digits, pneumonitis, and hepatomegaly [38]. Infants with natal or postnatal herpes commonly present 5-15 days post-natally and resemble bacterial sepsis: alterations in temperature, lethargy, respiratory distress, anorexia, vomiting, and cyanosis. The overall mortality rate from untreated, neonatal HSV infection is 49% and only 26% of survivors develop normally [26].

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