Childhood leukemias can occasionally exhibit tumor infiltration in the retina, optic disc, and uveal tract. It is characterized by a swollen optic disc and thickening of the retina and choroid, often with hemorrhage and secondary retinal detachment. Intraocular leukemic infiltrates are generally responsive to irradiation and chemotherapy, but they generally portend a poor systemic prognosis.
Retinoblastoma is a highly malignant intraocular tumor of childhood
Most children with unilateral retinoblas-
toma have the eye enucleated
Most children with bilateral retinoblastoma are treated with chemoreduction and thermotherapy
All children with retinoblastoma should have genetic analysis to establish the presence and site of the 13Q mutation Benign intraocular tumors of childhood are many and include choroidal nevus, congenital hypertrophy of the RPE, capillary hemangioma of the retina, and others Young children with retinal capillary hemangioma should be evaluated for von Hippel Lindau syndrome
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