Clinical Studies

Meta-analyses of mistletoe studies

Controlled clinical studies of VA-E in cancer treatment have been reviewed by Kiene (1989, 1996), and Kleijnen and Knipschild (1994). In a meta-analysis of mistletoe studies in bronchus carcinoma, colorectal carcinoma, mamma carcinoma, gastric cancer and femal genital cancer, Kleijnen and Knipschild (1994) reviewed 11 controlled trials in which at least unbiased allocation into the contracted treatment groups was attempted. The principal endpoint was mostly survival time. Four studies reported significant better results with VA-E, while six trials showed a positive trend. The authors stated that methodological quality of these studies was poor. The best designed and performed trial did not find significant differences between the VA-E group and the controls. In this study (Dold et al., 1991), a impressive number of complete remissions and partial remissions were observed both, in VA-E and so called "placebo group" which in fact was treated with a multi-vitamin-preparation. Thus, one cannot exclude the possibility that even in the control group, apart from

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