This technique is used mostly in Italy and Germany. The mechanism of action of O2-O3 mixture could be a direct effect on mucopolysaccharides with dehydration and shrinkage of the disc (Fig. 2). Other possible actions include an oxydative stress reduction of the cell-mediated process with inhibition of proteinase release, increase in immunosuppressor cytokines, and inhibition of inflammation and pain mediators (8).
Four milliliters of the O2-O3 mixture at a concentration of 27 to 30 mcg/mL are injected into the NP and 8 mL in the periradicular space through the same needle. Andreula et al. obtained 70.3% good and excellent results (Mac Nab criteria) in their experience on 300 patients (9).
FIGURE 2 Ozone therapy.
Was this article helpful?
Learn How Helping Others Benefits You And How You Can Begin Accomplishing Powerful Goals In The Process. The secrets behind Gaining Optimal Living and Inspiring Others.