Most metastatic tumors are adenocarcinomas with both histologic and cytologic features dependent on their site of origin. The more common primary sites include breast, lung, prostate, kidney, and thyroid (Figs. 25 and 26). Less likely candidates in the adult include small cell carcinoma of the lung, transitional cell carcinoma, and gynecologic carcinomas. A variety of epithelial immunohistochemical markers are now available which can help identify the site of origin for many of these tumors. This is particularly helpful if the tumor is poorly differentiated, thus limiting classification by histologic examination alone. In the pediatric population, the possibility of a metastatic neuroblastoma or rhabdomyosarcoma needs to be considered and
added to the differential list of small round blue cell tumors (27). A detailed clinical history is beneficial not only for diagnosis but also invaluable when selecting a panel of relevant immu-nohistochemical stains when working up a particular case.
Was this article helpful?
Deal With Your Pain, Lead A Wonderful Life An Live Like A 'Normal' Person. Before I really start telling you anything about me or finding out anything about you, I want you to know that I sympathize with you. Not only is it one of the most painful experiences to have backpain. Not only is it the number one excuse for employees not coming into work. But perhaps just as significantly, it is something that I suffered from for years.