Malignant Fibrous Histiocytoma

This high-grade sarcoma can exhibit all the varied histologic subtypes similar to its soft-tissue counterpart: storiform-pleomorphic, giant-cell-rich, myxoid, and inflammatory. The most common is the pleomorphic/storiform pattern in which there is an admixture of fibroblast-like spindle cells and highly pleomorphic tumor cells in a storiform histologic architecture. The nuclei of the tumor cells can be large and hyperchromatic (Fig. 19). The cytoplasm may be densely eosinophilic or contain vacuolar changes. Atypical mitotic figures are usually present and multiple. Malignant giant tumor cells as well as benign osteoclastic giant cells may be present (66). Most authors divide the tumors into low and high grade.

FIGURE 19 Malignant fibrous histiocytoma. Needle core biopsy containing pleomorphic spindle and histiocytoid giant cells (hematoxylin and eosin, original magnification x 10).

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Dealing With Back Pain

Dealing With Back Pain

Deal With Your Pain, Lead A Wonderful Life An Live Like A 'Normal' Person. Before I really start telling you anything about me or finding out anything about you, I want you to know that I sympathize with you. Not only is it one of the most painful experiences to have backpain. Not only is it the number one excuse for employees not coming into work. But perhaps just as significantly, it is something that I suffered from for years.

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