Langerhans Cell Histiocytosis

Eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease comprise this category. The disease can be focal as in eosinophilic granuloma (80% of cases), or involve multiple skeletal and extraskeletal sites as in Letterer-Siwe disease. The histologic and cytologic findings are similar in all subtypes. The tumor is made up predominantly of two components, Langerhans cells and eosinophils in varying quantities. Other inflammatory cells may also be present. The Langerhan cell is a round-to-oval histiocyte-like cell containing an oval nucleus and clearly demarcated cytoplasm. A prominent nuclear groove, which runs along the long axis, is present in most of these cells (Fig. 20). Cellular atypia as well as mitoses is minimal. Multinucleated giant cells and ordinary macrophages can be present. Eosinophils may be so

FIGURE 20 Langerhans cell histiocytosis. This high-power magnification contains eosinophils and Langerhans cells (hematoxylin and eosin, original magnification x 40).

prominent in the sample material that the term "eosinophilic abscess" has been used (67,9). Immunohistochemical stains will be positive for S-100 and CD1a (68).

Was this article helpful?

0 0
Dealing With Back Pain

Dealing With Back Pain

Deal With Your Pain, Lead A Wonderful Life An Live Like A 'Normal' Person. Before I really start telling you anything about me or finding out anything about you, I want you to know that I sympathize with you. Not only is it one of the most painful experiences to have backpain. Not only is it the number one excuse for employees not coming into work. But perhaps just as significantly, it is something that I suffered from for years.

Get My Free Ebook


Post a comment