This tumor occurs in the epiphyseal region of long bones in the skeletally mature, with 50% reported in the vicinity of the knee. The usual histologic appearance shows multinucleated giant cells uniformly distributed against the background of mononuclear cells, which are round
to oval in shape. There is cytologic similarity between the nuclei of the mononuclear cells and multinucleated giant cells (Fig. 23). Mitotic activity can be present and may be brisk in the mononuclear cells, but atypical forms are absent. Cartilage is not present unless there is a fracture. Osteoid formation can be identified in about half of the lesions in the vicinity of the advancing tumor edge. Secondary aneurysmal bone cyst change may complicate and, at times, obscure the giant cell tumor. Histologic grading of giant cell tumors has not been helpful in predicting the recurrence, local aggressiveness, or metastasis of these lesions (71,20).
Was this article helpful?
Deal With Your Pain, Lead A Wonderful Life An Live Like A 'Normal' Person. Before I really start telling you anything about me or finding out anything about you, I want you to know that I sympathize with you. Not only is it one of the most painful experiences to have backpain. Not only is it the number one excuse for employees not coming into work. But perhaps just as significantly, it is something that I suffered from for years.