This is usually not a problem when dealing with small lesions and most are not biopsied unless there are cosmetic considerations or symptomatology. A large slowly growing bone island or
FIGURE 3 Osteoma. Dense cortical lamellar bone is present in this example from the skull (hematoxylin and eosin, original magnification x 4).
surface osteoma of a long bone may cause suspicion of the sclerotic variant of osteosarcoma or parosteal osteosarcoma, respectively. However, the spindle cell stroma typical of both osteosar-coma subtypes will be lacking on histologic examination.
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