This uncommon histologic variant contains tumor cells with abundant clear cytoplasm and little matrix. Involvement of the epiphysis is common. Although the cells have abundant clear cytoplasm with sharply defined cell borders, the growth pattern is still lobular. Nuclei are large and may be binucleated. The limited matrix production is chondroid and calcifications may be present (55,56).
FIGURE 15 Mesenchymal chondrosarcoma. There is a mixture of small round primitive tumor cells and intervening cartilaginous foci (hematoxylin and eosin, original magnification x 10).
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