Angiotensin II bolsters GFR by selectively constricting the efferent glomerular arteriolar system, increasing glomerular capillary hydrostatic pressure. However angiotensin II also increases systemic vascular tone and stimulates aldosterone release, leading to renovascular hypertension. It should be apparent that treating renovascu-lar hypertension patients with drugs that inhibit ACE or antagonize the angiotensin receptor itself can lead to a sudden drop in GFR. The administration of these drugs also provides the basis of some of the functional tests for RAS.
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Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...