Conclusion

MRI has now a huge potential for evaluation of volumetric or intrarenal contrast changes due to medical renal diseases. Noninvasive functional techniques already

Figure 17 Longitudinal ex vivo T2*-weighted MR image of a rat kidney at very high field strength (9T) showing cortical low signal intensity areas related to magnetically labeled mesenchymal stem cells targeting the diseased areas of the kidney (homing effect) after intravenous administration. Abbreviation: MR, magnetic resonance.

Figure 17 Longitudinal ex vivo T2*-weighted MR image of a rat kidney at very high field strength (9T) showing cortical low signal intensity areas related to magnetically labeled mesenchymal stem cells targeting the diseased areas of the kidney (homing effect) after intravenous administration. Abbreviation: MR, magnetic resonance.

provide semiquantitative parameters with similar performances to scintigraphic techniques. They could also in the near future provide absolute values of perfusion and GFR, as well as specific criteria for characterization of nephropathies or pertinent information for prognosis, which could have an impact on new therapies. Labeling progenitors for in vivo follow-up of cell therapy could help in recognizing the homing sites and in evaluating efficacy of cell therapies.

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