Most Candida species are susceptible to amphotericin B and its lipid-based preparations. Azoles, such as fluconazole and itraconazole, are alternatives for infections caused by C. albicans; however, C. krusei and C. glabrata demonstrate significant resistance to these agents. Lipid-based amphotericin B preparations are less nephrotoxic as compared to conventional amphotericin B. This benefit is offset by greater expense and less clinical experience with their use. New antifun-gal agents such as caspofungin, an echinocandin, and voriconazole, a triazole, have activity against Candida species, but extensive clinical experience is lacking. Potential drug interactions exist for both the azoles and the echinocandins with the immunosuppressant agents.

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