Recent studies have demonstrated that voriconazole has greater efficacy than amphotericin B for the treatment of invasive aspergillosis. This offers some promise given that invasive aspergillosis carries an 80% to 100% mortality rate, even with the use of amphotericin B. Caspofungin is also approved for the treatment of refractory aspergillosis. Extensive clinical experience with these new agents is lacking, and the role of combination therapy for invasive mold infections has not been studied.

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