Transplantation Between Closely Related Primate Species

Clinical application of xenotransplantation has been limited almost exclusively to the use of nonhuman primates as organ donors. Indeed, encouraging results have been obtained with the transplantation of primate kidneys, hearts and livers into humans.

The first attempt at primate-to-human xenotransplantation was by Unger, who, in 1910, performed a chimpanzee-to-human renal transplant. The graft clotted and the recipient died. Over 50 years later, primate-to-human renal xenotransplantation was again attempted, with markedly improved results. In 1964, Reemtsma and colleagues performed a series of chimpanzee-to-human renal transplants, achieving nine-month graft survival in one patient. Baboon-to-human renal transplants were attempted by Starzl, who noted poorer graft survival-despite an immunosuppressive protocol similar to the one used by Reemtsma. Although chimpanzee xenografts fared better than baboon xenografts, the rejection process was characterized in both by the infiltration of recipient cellular elements. Rejection of primate renal xenografts appeared to resemble an aggressive form of clinical

0 0

Post a comment