Tolerant Receptor Repertoire

The TCR repertoire of Vpendo+Vp5-CD4+ T cells from Mtv-8+ Vp5 Tg mice is so diverse that it effectively recreates the nontransgenic TCR- p chain repertoire within each individual mouse.21 This diversity is apparent even at the molecular level, of individual rearrangements of one particular Vp gene element to one particular Jp element. These newly generated TCRs can deliver proliferative signals upon antibody-mediated crosslinking, and are therefore fully functional. Vpendo+CD4+ T cells from Vp5 Tg mice do not appear to be autoreactive, either in vivo or in vitro.21

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