Tcell Regulation

Evidence for the existence of regulatory T cells does not come exclusively from studies of transplantation tolerance. Regulatory T cells have been found in several

Figure E4.1. Demonstration of linked suppression. This requires the demonstration that tolerant animals accept grafts where a third party antigen is present in cells that also have the tolerated antigens (BxC), but reject third party grafts (C) if the tolerated antigen absent from the graft cells (even if a concomitant tolerated-type graft (B) is given). The animals that accept the grafts with the "linked" third party antigen (BxC) should accept later grafts of the third party (C).

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