Results Of Lung Transplantation

The success of lung transplantation demands attention to detail. Early results have improved secondary to refinements in donor and recipient selection, operative technique, and post-operative management.15 Operative mortality rates have decreased as transplant centers acquire expertise in the management of these patients.30

Long Term Survival

As of the January 2002 update, the Registry of the International Society for heart and Lung Transplant contained survival data on 14,588 lung transplants from programs worldwide with up to 7 years of follow-up. Actuarial survival data for the reported international experience at 1,3, 5, and 7 years was 71%, 57%, 46%, and 36%, respectively. The half-life and the conditional half-life are longer after BLT than after SLT. Survival is significantly better after BLT than SLT for patients with COPD and alpha-1-antitrypsin deficiency emphysema. However, this does not apply for recipients with PPH or IPF. Actuarial survival by diagnosis does not differ substantially between the different groups.

Functional Results

In general, the functional results after lung transplantation have been excellent for all of the diagnostic groups. In patients with emphysema, BLT consistently results in significantly greater post-operative improvements in FEVj, arterial oxygen tension, and exercise tolerance compared to SLT.

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