Successful pregnancy is rare in patients on maintenance dialysis. While it is not common, successful pregnancy can be achieved in many patients posttransplantation. As with other renal disease, degree of renal function offers the best prognostic sign of any parameter. Patients with creatinines less than 2 mg/dl have the greatest likelihood of successful full term pregnancy. As renal function decreases, the chances of successful pregnancy fall.

The effect of pregnancy on allograft function can be variable. In patients with good baseline function, pregnancy is well tolerated. During pregnancy, GFR may increase as may proteinuria. In patients with compromised renal function, pregnancy may have an adverse effect on allograft function and survival.

Pregnancy-induced hypertension and pre-eclampsia occur approximately four times more frequently in transplant recipients as in normal pregnancies. The diagnosis of pre-eclampsia is difficult in these patients and may require close follow-up of the patient. Urinary tract infections are more frequent in pregnancy as is allograft pyelonephritis.

Numerous normal pregnancies have been reported for women who have been on cyclosporine, azathioprine, and prednisone. While there are theoretic concerns with the use of these agents in pregnancy, none of them are absolutely contrain-dicated in pregnancy. Newer agents, e.g., mycophenolate mofetil and rapamycin, have unknown effects and at this writing, should be avoided if conception is contemplated.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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