P450 3a4

• St. John's Wort • Orlistat Reduced Clearance with Cyclosporine

• Grapefruit and grapefruit juice can increase cyclosporine concentrations

Other

• Vaccinations—live vaccinations should be avoided

Formulations

• Neoral 25 mg and 100 mg soft gelatin capsules in 30-count blister packages

• Oral solution 100 mg/ml in bottle containing 50 ml

• Gengraf 25 mg and 100 mg capsules in 30-count unit dose packages

• Eon cyclosporine 25 mg and 100 mg capsules in 30-count unit dose blisters

• Sidmak cyclosporine 25 mg and 100 mg capsules in 30-count unit dose blisters

Dosage

NOTE: Neoral and Sandimmune are not bioequivalent and should not be used interchangeably. Neoral has increased bioavailability and this should be taken into consideration when making dosing decisions.

• Daily dose should be given as two divided doses on a consistent schedule

Newly Transplanted Patients

• Initial dose of Neoral should be the same as a Sandimmune dose. Suggested initial doses include:

- 9 ± 3 mg/kg/day for kidney transplant patients

- 8 ± 4 mg/kg/day for liver transplant patients

- 7 ± 3 mg/kg/day for heart transplant patients

• The dose is then subsequently adjusted to achieve a predefined cyclosporine blood concentration

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