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Table 13A.4. Pediatric heart transplant immunosuppression—ISHLT, 20025

Posttransplant % of Children on Various Immunosuppression Drugs

Table 13A.5. ISHLT categories of acute cellular rejection14

• Grade 0-no evidence of cellular rejection

• Grade 1A-focal perivascular or interstitial infiltrate without myocyte injury

• Grade 1B-multifocal or diffuse sparse infiltrate without myocyte injury

• Grade 2-single focus of dense infiltrate with myocyte injury

• Grade 3A-multifocal dense infiltrates with myocyte injury

• Grade 3B-diffuse, dense infiltrates with myocyte injury

• Grade 4-diffuse and extensive polymorphous infiltrate with myocyte injury; may have hemorrhage, edema, and microvascular injury

(ALG) for induction therapy. We have only used OKT3 and ATG for rescue therapy of severe rejection.

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