Info

Brand Name

Deltasone®

Company

Pharmacia and Upjohn, Inc.

Class

• Anti-inflammatory steroid

Mechanism of Action

• Causes emigration of circulating T cells from intravascular tissue compartment to lymphoid tissue

• Inhibits production of T cell lymphokines that are needed to amplify macrophage and lymphocyte response

Application in Transplantation

• Immunosuppressive adjunct for the prevention and treatment of solid organ rejection

Contraindications

• Hypersensitivity to prednisone and/or its components

• Systemic fungal infection

Warnings

• May produce posterior subcapsular cataracts, glaucoma, and may enhance the establishment of secondary ocular infections due to fungi or viruses

• Increased calcium excretion

• Vaccination should not be undertaken during therapy

• Adequate human reproduction studies have not been undertaken

Special Precautions

• Use with caution in patients with hypothyroidism, cirrhosis, ocular herpes simplex, hypertension, congestive heart failure, and ulcerative colitis

• Psychologic derangements may occur while on therapy

Adverse Reactions

• Sodium and fluid retention, congestive heart failure in susceptible patients, potassium loss, hypokalemic alkalosis, hypertension

• Muscle weakness, steroid myopathy, loss of muscle mass, vertebral compression fractures, aseptic necrosis of humeral and femoral heads, pathologic fracture of long bones, osteoporosis

• Peptic ulcer with possible perforation and hemorrhage, pancreatitis, abdominal distension, ulcerative esophagitis

• Impaired wound healing, thin fragile skin, petechiae and ecchymoses, facial erythema, increased sweating, suppressed reaction to skin tests

• Pseudotumor cerebri, convulsions, vertigo, headache

• Cushingoid state, suppression of growth in children, secondary adrenocortical and pituitary unresponsiveness, menstrual irregularities, decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic agent

• Posterior subcapsular cataracts, increased intraocular pressure, glaucoma, exophthalmos

Drug Interactions

• Salicylates • Vaccines • Toxoids

Dosage Strengths

• 2.5 mg tablets • 5 mg tablets • 10 mg tablets

• 20 mg tablets • 50 mg tablets

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