Derbinski J, Schulte A, Kyewski B, Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2001; 2:1032-9. Stockinger B. T lymphocyte tolerance: From thymic deletion to peripheral control mechanisms. Adv Immunol 1999; 71:229-65.

Ohashi PS, Ochen S, Buerki K, Pircher H, Ohashi CT, Odermatt B, et al. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 1991; 65:305-17.

Schonrich G, Kalinke U, Momburg F, Malissen M, Schmitt-Verhulst AM, Malissen B, et al. Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell 1991; 65:293-304. Rocha B, Grandien A, Freitas AA. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J Exp Med 1995; 181:993-1003. Fink PJ, Shimonkevitz RP, Bevan MJ. Veto cells. Annu Rev Immunol 1988; 6:115-37. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000; 101:455-8.

Mellor AL, Sivakumar J, Chandler P, Smith K, Molina H, Mao D, et al. Prevention of T cell-driven complement activation and inflammation by tryptophan catabo-lism during pregnancy. Nat Immunol 2001; 2:64-8.

Uematsu Y, Ryser S, Dembi'c Z, Borgulya P, Krimpenfort P, Berns A, et al. In transgenic mice the introduced functional T cell receptor b gene prevents expression of endogenous b genes. Cell 1988; 52:831-41.

Fink PJ, Fang CA, Turk GL. The induction of peripheral tolerance by the chronic activation and deletion of CD4+Vb5+ cells. J Immunol 1994; 152:4270-81. Blish CA, Gallay BJ, Turk GL, Kline KM, Wheat W, Fink PJ. Chronic modulation of the T cell receptor repertoire in the lymphoid periphery. J Immunol 1999; 162:3131-40.

Scherer MT, Ignatowicz L, Pullen A, Kappler J, Marrack P. The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire. J Exp Med 1995; 182:1493-504. Fink PJ, McMahan CJ. Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe. Immunol Today 2000; 21:561-6. McMahan CJ, Fink PJ. RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells. Immunity 1998; 9:637-47. McMahan CJ, Fink PJ. Receptor revision in peripheral T cells creates a diverse Vb repertoire. J Immunol 2000; 165:6902-7.

Yu W, Nagaoka H, Jankovic M, Misulovin Z, Suh H, Rolink A, et al. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 1999; 400:682-7.

Lantelme E, Palermo B, Granziero L, Mantovani S, Campanelli R, Monafo V, et al. Recombinase-activating gene expression and V(D)J recombination in CD4+CD3low mature T lymphocytes. J Immunol 2000; 164:3455-9.

Lantelme E, Mantovani S, Palermo B, Campanelli R, Granziero L, Monafo V, et al. Increased frequency of RAG-expressing, CD4+CD3low peripheral T lymphocytes in patients with defective responses to DNA damage. Eur J Immunol 2000;30:1520-5. Fink PJ, Swan K, Turk G, Moore MW, Carbone FR. Both intrathymic and peripheral selection modulate the differential expression of Vb5 among CD4+ and CD8+ T cells. J Exp Med 1992; 176:1733-8.

Huang CY, Golub R, Wu GE, Kanagawa O. Superantigen-induced TCRa locus secondary rearrangement: role in tolerance induction. J Immunol 2002;168:3259-65. Hiom K, Melek M, Gellert M. DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations. Cell 1998; 94:463-70.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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