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Fig. 7.2. The number of patients in the U.S. waiting for an SPK transplant, receiving an SPK transplant and the number of cadaver organ donors per year.

effects on associated secondary complications may also be achieved, but conclusive studies have not been performed.

The contraindications to pancreas transplantation include the majority of patients with type 1 diabetes that have normal renal function and do not exhibit a brittle course, or hypoglycemic unawareness, or any evidence of nephropathy. For patients that do have an indication for pancreas transplantation, it is important to rule out significant medical contraindications in a similar manner as applies to other areas of transplantation. These issues include: recent malignancy, active or chronic untreated infection, advanced forms of major extrarenal complications (i.e. coronary artery disease), life expectancy of less than 1 year, sensitization to donor tissue, noncompliance, active substance abuse, and uncontrolled psychiatric disorder.

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