The mainstay of immunosuppression is triple drug therapy, including cyclosporine, azathioprine and corticosteroids (Table 11.5).


Cyclosporine is administered postoperatively in a dose of 2.5-5.0 mg/kg/day and may be given intravenously or orally. This dose is then used as maintenance therapy and adjusted based on levels and interaction with other medications. The side effects of cyclosporine include nephrotoxicity, which is dose-related. Hypertension is a frequent side effect, as are tremor and paresthesias.


Azathioprine (Imuran) is administered orally or intravenously in the postoperative period in a dose of 2 mg/kg/day. The dose is adjusted to keep the WBC count greater than 4000. Drug interactions are not as common, although given in

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook

Post a comment