How Can This Knowledge Translate To The Clinic

Current immunosuppressive agents, although the best option available, are far from being ideal drugs. However, their known efficacy in preventing acute al-lograft rejection makes it ethically difficult to displace them in clinical trials of potential tolerogenic drugs. CsA is known to hinder tolerance induction with therapeutic mAbs.39 Is it wise though to give transplanted patients an experimental therapeutic regime in the absence of CsA?

One reason why CsA exerts a tolerance-blocking effect is due to its capacity to interfere with AICD.39 In fact, both CsA and sirolimus (FK506) are calcineurin inhibitors that block transcriptional activation of the IL-2 gene in response to

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