Fev Fev Fev

FEF (percent of baseline)

*Best postoperative FEVj is defined as the average of two postoperative best FEVj measurements, 3 to 6 weeks apart.

•Grades 0 to 3 are subdivided into category A, without pathologic evidence of obliterative bronchiolitis, or category B, with pathologic evidence of obliterative bronchiolitis.

as ATGAM (10-20 mg/kg/d for 10 to 14 days) or OKT3 (5 mg/d for 10 to 14 days) may be utilized.57 Options for more recalcitrant disease include switching from cyclosporine to tacrolimus based immunosuppression and total lymphoid irradiation. Tacrolimus rescue therapy has been shown to be effective in stabilizing pulmonary function in patients with BOS.58-60 Although many patients show some improvement with augmented immunosuppression, the relapse rate remains high and patients remain at risk of steady progression of the disease and death. Retransplantation has been performed in selected patients with varying degrees of success.46

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