Endothelial Disruption

Endothelial disruption leads to a loss of vascular integrity allowing circulating blood cells and clotting factors, usually isolated from surrounding thrombogenic tissues, to initiate procoagulant and proinflammatory events. With electron microscopy (EM), endothelial cell changes can be detected prior to their disruption in rejecting xenografts. In vitro morphologic changes have also been described using light microscopy. While destruction of cell membrane integrity appears to be the primary mechanism for endothelial disruption with CML and ADCC, apoptosis of PAECs has also been demonstrated in vitro following exposure to xenoantibodies.

0 0

Post a comment