E2

in the same way a developing thymocyte would—by upregulation of RAG expression and generation of alternate TCR genes whose protein products will be tested for their signaling capacity. Thus, rather than being selected for directly, TCR revision may be a byproduct of the way in which the TCRs expressed by developing thymocytes are selected to meet the dual requirements for self tolerance and recognition of foreign peptides in the context of self MHC molecules. The added flexibility in immune recognition provided to the aging mouse by TCR revision could then be considered an unexpected bonus.

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