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Is TCR revision associated with an increased risk of autoimmunity, illegitimate recombination, or susceptibility to pathogens thought to express superantigens?

It is these three areas that are most likely to be impacted negatively by TCR revision. Will cells undergoing TCR revision be found at the site of tissue-specific autoimmunity? Can the expression of RAG genes in T cells within the lymphoid periphery lead to chromosomal translocations within the TCR loci? Will the loss of superantigen-reactivity in T cells increase an individual's susceptibility to pathogens expressing superantigens?

Clearly, many key questions remain to be answered as this newly discovered means of peripheral T cell tolerance induction is explored.

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