Cyclosporine Capsules and Oral Solution Modified contd

Conversion from Sandimmune to Neoral

• Neoral should be started with the same daily dose as was previously used with Sandimmune (1:1 dose conversion)

• The Neoral dose should then be adjusted to achieve preconversion cyclosporine blood trough concentrations

• Until cyclosporine blood trough concentrations reach preconversion levels, monitoring should be undertaken every 4 to 7 days

Editors Notes:

Cyclosporine has been used in clinical transplantation for nearly 20 years. However, it is clear that trough monitoring of CSA is the best way to monitor for adequate immunosuppression. Recently, C2 monitoring is being advocated as better than trough monitoring for better efficacy and preventing toxicity. The CSA blood level at 2 hours (C2) is a more consistent and reliable measure of the absorption of cyclosporine. (Cyclosporine microemulsion (Neoral) absorption profiling and sparse-sample predictors during the first 3 months after renal transplantation. ©2002 Am J Transplant)

0 0

Post a comment