Choosing The Best Donor

The best donor is usually a blood relative. If there are multiple family members who are suitable donor candidates, it is logical to proceed with evaluation of the relative who is best MHC-matched to the transplant recipient. The best match possible is an identical twin, followed by a MHC-identical (two haplotype match) sibling, then a single haplotype matched parent or sibling. However, non-immunologic considerations, such as donor geographic location, age, occupational risk, and familial responsibilities need to be considered. If a suitable blood relative is not found, then emotionally-related donors can be considered. However, it is imperative to ensure the altruistic motivation of the donor in these circumstances.

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