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Table 8.2. Contraindications for islet transplantation age less than 18 years

Body weight >75 kg

Body mass index >26 (female), >27 (male) kg/m2

Insulin requirement of >0.7 IU/kg/day or >50 IU per day (whichever is less)

Positive C-peptide response (>0.2 ng/mL) to oral or intravenous glucose tolerance testing

Creatinine clearance <80 ml/min/1.73 m2

Positive pregnancy test or failure to follow effective contraceptive measures Active infection including hepatitis C, hepatitis B, HIV, or tuberculosis Invasive aspergillus infection during the previous 12 months

History of malignancy (except for treated squamous or basal cell carcinoma of the skin) Active alcohol or substance abuse

History of nonadherence to prescribed medical regimens

Psychiatric disorder that is unstable or uncontrolled on current medication

Inability to provide informed consent

Severe coexisting cardiac disease, characterized by any 1 of these conditions: recent myocardial infarction (within past 6 months); angiographic evidence of noncorrectable coronary artery disease; evidence of ischemia on functional cardiac exam; left ventricular ejection fraction <30%

Baseline liver function tests outside of normal range or history of significant liver disease Gallstones or hemangioma in liver, on baseline ultrasound examination History of coagulopathy or medical condition requiring long-term anticoagulant therapy Active peptic ulcer disease

Severe gastrointestinal disorders potentially interfering with the ability to absorb oral medications

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