Antithymocyte Globulin Equine contd

Editors' Notes:

ATGAM® and Thymoglobulin® are the only two polyclonal antilymphocyte preparations which are currently available. ATGAM® is an immunoglobule against lymphocytes prepared in horses; Thymoglobulin® is prepared in rabbits. ATGAM® causes less leukopenia than Thymoglobulin®. Both agents have been used to prevent acute rejection after transplantation and to treat acute rejection episodes.

Treatment of Rejection

• 10 mg/kg/d IV for 8-14 days, then every other day up to 21 doses Dose should be infused at least over 4 hours, through a 0.2-1 micron filter

Appendix I

Antithymocyte Globulin (Rabbit)

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