Traditional Chinese Medicine

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Chinese Medicine

Chinese medicine, or traditional Chinese medicine, is thousands of years old and one of the most traditional healing systems on earth. Central to Chinese medicine is the principle of qi, or energy, which travels along invisible meridians, on the surface of the body, and through internal organs. A balance of this energy is crucial for maintaining good health. To a physician of Chinese medicine, The polarities of yin and yang are an important aspect of Chinese medicine, describing the interdependence and relationship of opposites. Yin refers to the tissue of an organ and yang to its activity. A yin deficiency means the organ does not have enough raw materials to function in a yang deficiency, the organ does not react adequately when needed. The organs of the body work synergistically, each one either nourishes or inhibits the proper functioning of another. In China, methods for conducting clinical studies differ from the West in that they consider giving a placebo to a sick person...

Clinical Studies With Chinese Herbal Formulas

No discussion on using natural immunostimulant compounds in cancer therapy would be complete without some consideration of the many clinical studies that have been done in China. Studies have been conducted on the combined use of chemotherapy and Chinese herbal medicine, as well as on the anticancer use of Chinese herbal medicine alone. The majority of herbal formulas used in the Chinese studies were composed primarily of immunostimulant herbs such as those in Table 12.1 (for example, most formulas included Astragalus or ginseng or both). In Chinese herbal medicine, most of these herbs are considered tonics for the qi, or vital energy.3 (For contents of the herbal formulas mentioned below, see Table H.2 in Appendix H for more information on the theory of using Chinese herbs in cancer treatment, see reference 68). a Herbs that in Chinese herbal medicine terms clear heat,

Nasopharyngeal Cancer

In a study on 197 patients with stage III and IV naso-pharyngeal cancer, approximately half had radiotherapy in combination with Formula 1, and half received radiotherapy alone. After one year, survival was 91 percent in the combined treatment group and 80 percent in the one receiving only radiotherapy. After three years, the survival rates were 67 percent and 33 percent respectively, and after five years, they were 52 percent and 24 percent.71,72 Although Formula 1 contains Astragalus, most of the others in the formula are ones that, in Chinese herbal medicine terms, reduce blood stagnation.

Safety of Synergistic Combinations

There is also a precedent for safely using large combinations of natural compounds, including combinations that contain some of the compounds in this book. Both Chinese herbal medicine and Ayurvedic medicine, the ancient healing system of India, have been using large combinations of natural compounds for centuries, if not thousands of years. For example, in Chinese herbal medicine, single herbs are rarely prescribed, but combinations of 4 to 12 herbs are commonly employed. Considering that each herb may contain multiple active compounds, this is a large mix of compounds. The efficacy and safety of many of these formulas have been borne out by modern Chinese investigations.

Types of Complementary Therapies

Encourage changes in behavior or symptom relief. Visualization and imagery techniques involve the induction of a relaxed state followed by use of a visual image, such as a pastoral scene, that enhances the sense of relaxation. Progressive relaxation involves sequential tensing and relaxing of muscles. Acupuncture. Acupuncture is the insertion of very fine needles at special points on the body. Although details of practice may differ between individual schools, all traditional Chinese medical theory is based in the Taoist concept of yin and yang and the flow of Qi (energy) along hypothesized channels in the body. Stimulating acupuncture points situated on these channels provides one way of altering the flow of energy. Modern scientific understanding views acupuncture points as corresponding to physiologic and anatomic features such as peripheral nerve junctions. Massage. Therapeutic massage involves manipulation of the soft tissue of whole or partial body areas to induce general...

Summary of Research and Conclusions

Although Astragalus is one of the most commonly used Chinese herbs and is used extensively in Chinese hospitals for treating cancer patients (in combination with chemotherapy), relatively few studies on Astragalus are indexed in the MEDLINE database. Presumably, many more are available in Chinese journals. Because of the custom of using combinations in Chinese herbal medicine, most of the indexed studies of Astragalus are ones on herbal combinations.

General Information

In Chinese herbal medicine, Eleutherococcus (or Acanthopanax) is used as a qi tonic and as an anti-inflammatory agent in arthritic conditions. The dose is commonly 6 to 15 grams per day of the dried herb in decoction.57 The Russian studies commonly used a 33 percent (1 3) alcohol extract, of which 2 to 16 milliliters were taken 1 to 3 times per day this dose is roughly equivalent to 1 to 16 grams per day of the dried herb. Treatment was commonly continued for up to 60 days, followed by a rest period of 2 to 3 weeks.56 As noted earlier, some type of treatment-rest schedule may help

S Evidence statement

Two further RCTs (Ib) and two CCTs (IIa) examined the interventions of t'ai chi, Chinese medicine, relaxation training and a multimodal intervention program. The results of the CCT assessing t'ai chi reported significant changes in patients' assessment of their symptoms at three month follow-up.457 One CCT of a multimodal intervention program reported significant effects on five of the eight areas assessed. These included two measures of list learning and memory, improved BDI scores, one measure of grip strength and one of tactile sensitivity458 (IIb). One of the RCTs looked at relaxation training and biologically orientated imagery treatment.459 The results showed a significant improvement on state anxiety, but not on trait anxiety or the other three tests examining mood or health states. The last RCT compared the efficacy of traditional Chinese medicine combined with Western medicine to treatment with Western medicine alone. The results indicated beneficial effects upon remittance...

Estimated Therapeutic and Loael Doses of Arctigenin and Arctium Seed

The commonly prescribed dose of Arctium seed for noncancerous conditions in Chinese herbal medicine is about 9 grams per day, which provides about 500 milligrams of arctigenin. The LOAEL dose for arctigenin is uncertain, but based on predictions for the LD50, we will estimate it at 650 milligrams, or 12 grams of Arctium seed (see Appendix J) this is the tentative dose recommendation listed in Table 20.6.

Acupuncture for Pelvic Floor Dysfunction

Acupuncture is an important mainstay of traditional Chinese medicine (TCM). Empirically derived by thousands of years of observation, Chinese medical doctors recorded their treatments almost 2000 years ago in the then modern text, Yellow Emperor's Book of Internal Medicine. Although the physiologic reasoning may seem bizarre to modern allopathic physicians, accepting and understanding the basic tenets does then provide a logical choice of therapy that has withstood the test of time,longer than any current Western therapeutics. Every patient, both responsive and unresponsive to conventional medical therapy, should be given the choice of undergoing a course of acupuncture. Pelvic floor dysfunction and, in particular, pelvic pain, represents as much a dilemma for TCM acupuncture as it does for Western medicine. Precise diagnoses are difficult to differentiate. Indeed, every medical condition mentioned in this book can cause pelvic dysfunction in male and females. Acupuncture does have a...

Syndromes related to a cultural emphasis on fertility and procreation Genital shrinking syndrome koro suoyang

The 'genital shrinking' syndrome is a transient state of acute anxiety associated with vegetative symptoms, in which the affected male subjectively experiences a shrinking of his penis and the affected female a shrinking of her breasts and or labia the sufferers anticipate not only impotence or sterility but, in the case of complete genital retraction, certain death. Moreover, the immediate human environment of the sufferers is convinced of the same outcome and this explains the 'life saving' measures commonly taken, such as holding on to the sufferer's genitals manually or with special instruments. The 'genital shrinking' syndrome came to the attention of European psychiatry in the late nineteenth century through reports of colonial physicians working in Southeast Asia and through the growing interest in traditional Chinese medicine. Chinese traditional medicine interprets suo-yang as yin-yang imbalance due to a deficiency of the 'warm' male principle yang and an excess of the 'cold'...

Replacement of Blastoderms into the Ring Cultures and Completion of Setting Up

The depth of TCM BSS must be increased at this stage to facilitate pipet transfer (while preserving some of the oligo concentration around embryos). This added medium should be prewarmed to near-incubation temperature (see above). By gently oscillating the dish, blowing with a fine medium-filled pipet, or the use of forceps, it should be ensured that each blastoderm is individually prepared for the rapid pipet transfer of the following step by being free-floating, and not stuck to the plastic floor of the dish. This is much easier for those incubated epiblast-up. 2. Lift the ring membrane assembly at one point (with the small curved-toothed forceps) and withdrawing the remaining fluid from beneath it using the special bent, fine smooth-mouthed pipet. Rolling the ring around helps remove more of this underlying saline, and having the overlying space about one-third filled with TCM BSS also helps by pressing saline out more thoroughly from beneath. The optimal pipet is so angled that...

Using Combinations Of Polysaccharides

Combinations of herbs are of course used in Chinese herbal medicine, and most Chinese formulas intended for immune stimulation (or qi stimulation) contain poly-saccharide-rich herbs. For the interested reader, we mention two historic Chinese herbal formulas as examples. These formulas, Shi Quan Da Bu Tang and Bu Zhong Yi Qi Tang, contain combinations of both poly-saccharide- and saponin-rich herbs (see Table H.2 in Appendix H for ingredients). Each formula is put to a slightly different use in Chinese herbal medicine, but both produce effects on the immune system.

HaiLu Zhao Peter CY Tong Juliana CN Chan

This review focuses on the efficacy and safety of Chinese medicine in the treatment of type-2 diabetes. Included were 84 controlled clinical studies of type-2 diabetes treated with Chinese medicine for at least 1 month. Reported outcomes were symptom relief improvement in glycemia, insulin resistance and secondary failure, and adverse events. Symptom relief was achieved in most (> 80 ) of the patients receiving Chinese medicine. Compared with orthodox drugs, Chinese medicine had a 1.2-fold (95 CI 1.2-1.3) increase in symptom relief. The relative risk of achieving a fasting blood glucose of < 7.3mmol l or a postprandial blood glucose of < 8.2mmol l was 3.0 (95 CI 1.4-6.5) for Chinese medicine plus diet versus diet 2.0 (95 CI 1.4-3.0) for Chinese medicine versus placebo 1.8 (95 CI 1.4-2.3) for combined Chinese medicine and orthodox drugs versus Yuquan Wan (a classic Chinese herbal formula for diabetes), 1.5 (95 CI 1.4-1.7) for combined Chinese medicine and orthodox drugs vs....

Roller Bottle Culture After Oligo Treatment

Embryo Culture Roller

Our current roller-culture medium is 100 Liebovitz TCM as above, plus 5 (when oligos are in medium) to 20 fetal calf serum. We already have evidence for necrosis, however, particularly in the notochord floorplate region of the cross-section, in advanced embryos following growth in this medium. It is very likely that serum-free media, such as those developed for advanced chick organ culture (e.g., 18), will give even better and more extended development, since these and other authors have evidence for toxicity of serum to chick embryo structures. This offers the exciting possibility that half-life of phosphorothioate oligos in such cultures could be prolonged, since serum frequently contains exonucleases. Since we have not yet done the necessary testing ourselves, we draw attention to this, but do not detail the alternative media. 1. Remove the oligo incubation dish from incubator, and place on a warm bench or in a larger dish with a layer of warm water, thus avoiding cooling shock to...

Botanical Herbal Medicines Used Against Cancer

Essiac was popularized by a nurse, Rene Caisse, who claims to have derived the formula from a traditional native healer. This product consists of four herbs burdock root, Turkey rhubarb, sorrel, and slippery elm. A review in the Canadian Medical Association Journal reported no published research on Essiac.37 Mistletoe. Mistletoe extracts, which are more widely known by the trade names Iscador, Helixor, and Eurixor, are popular cancer treatments in Europe and are available in some mainstream European cancer clinics. Unlike many botanical treatments, mistletoe extracts have been subjected to randomized trials in cancer patients. A systematic review of early trials revealed small sample sizes and serious methodologic shortcomings in most studies.38 In subsequent larger studies, no survival benefit was found in patients with malignant melanoma39 or head and neck cancer.40 A small trial in glioma reported possible benefit in a subgroup, but there were no overall differences between...

Herbal Immunostimulant Compounds

The (probable) active ingredients of the herbal compounds in Table 12.1 tend to fall into a limited number of chemical families one of these is high-molecular-weight polysaccharides, which are large sugar molecules. Natural compounds containing them include Astragalus, Ganoderma, Eleutherococcus, and PSK. A second family of immunostimulating compounds is the saponins. Natural compounds with these are Eleuthero-coccus and ginseng. It is tempting to speculate that the most effective combinations of herbal immune stimulants will contain compounds from both families, and in fact, most multiherb, immunostimulating formulas used in Chinese herbal medicine do have both. Some herbs

Organization

This book is a continuation of my first book, Cancer and Natural Medicine.14 There are, however, some significant differences between the two. Whereas the first book discussed nearly two hundred natural compounds that may be useful, this book narrows that list to about three dozen judged to have the greatest potential or to be of the greatest interest. Furthermore, the discussions on clinical considerations here are more advanced. The reader is referred to my first book for information on theories of Traditional Chinese Medicine (TCM) in cancer treatment, Eastern and Western psychological therapies in cancer treatment, and additional natural compounds that may be useful in cancer treatment, including many Chinese herbs.

Methods

Methods for oocyte collection, maturation, and somatic cell preparation are described in other chapters of this book as well as in our earlier publications (8,12). Briefly, 25 oocyte-cumulus cell complexes were matured in each well of a 4WD filled with 400 L of bicarbonate buffered TCM 199 medium with additives, hormones, and 15 cattle serum, covered with 400 L of oil. Fibroblasts were cultured in wells of a 4WD containing 400 L of Dulbecco's modified Eagle's medium supplemented with additives and 10 cattle serum (see Note 1) and covered with 400 L of oil for 3 to 5 d to reach almost total confluence. For one routine HMC program, 150-200 oocytes and one well of somatic cell culture were used.

Reagents

Tissue culture medium (TCM)-199H (GIBCO). 4. Maturation medium TCM-199H supplemented with 0.02 U mL bovine luteiniz-ing hormone and 0.002 U mL bovine follicle-stimulating hormone (Sioux Biochemicals, Sioux Center, IA), 1 g mL estradiol P-17, 0.2 mM sodium pyruvate, 50 g mL kanamycin, 100 M cysteamine, and 10 heat-inactivated estrus goat serum (produced at Nexia). 9. Postfusion medium comprises TCM-199H plus 10 fetal calf serum supplemented with 7.5 g mL cytochalasin B.

Lignans

Lignans are widely distributed in the plant kingdom, with several hundred lignan compounds isolated in about 70 different families.64 Lignans may produce a number of medicinal effects. For example, many appear to have liver-protective properties, including silybin from milk thistle (Silybum marianum) and schizandrin from Schizandra chinensis, both of which are used in herbal medicine. Some lignans have caused cytotoxic effects in cancer cells, an example being podophyllo-toxin, obtained from the mayapple plant (Podophyllum peltatum). In fact, the FDA has approved its semisyn-thetic derivatives teniposide and etoposide as anticancer drugs. In this section, we focus on two lignan-containing plants, Arctium lappa (burdock), which is used in Chinese herbal medicine, and flaxseed, which is used as a food and a bulking agent for treating constipation. Arctium seed contains the plant lignan arctigenin, and flaxseed contains secoisolariciresinol (SECO), a precursor for the production of...

Eye Problems

Glutathione, an antioxidant, is found to be especially lacking in cataracts as well as vitamin C, vitamin E, and folic acid. Vitamin A and the carotenoids are important for eye health, lutein a carotenoid is found in the lens. Foods containing these antioxidants are fruits and vegetables, spinach and other green leafy vegetables, broccoli, asparagus, legumes, avocados, oranges, dark berries, plums, and cherries. The herb bilberry is high in antioxidants, 240 to 480 mg of extract daily are recommended to protect the lens and retina, as are rosemary, turmeric, and ginger. Homeopathy remedies include Calcarea carbonica, Calcarea fluorica, Causticum, Natrum muriaticum, phosphorus, and Silicea. Take remedy according to symptom. Chinese medicine includes wolf-berry, chrysanthemum, and rumania. wash made from an infusion of calendula, eye-bright, or chamomile, kept sterile, can reduce swelling and redness add goldenseal if there is an infection. Use echinacea, eyebright, sage, and goldenseal...

Ginseng

Panax ginseng is a commonly used medicinal herb. It is categorized as a qi (vital energy) tonic in Chinese herbal medicine, and its use dates back more than 3,000 years. The main active constituents of ginseng are gin-senoside saponins. Although at least 28 ginsenosides have been identified, these can be classified into one of three groups, Ro, Rb, and Rg.a The quantity of these saponins in four-year-old roots is about 0.4, 2.3, and 1.1 percent respectively, for a total saponin content of about 3.8 percent.106 However, in another study on different ginseng samples obtained from herb shops in Taiwan, the average total saponin content was about half this amount, or 1.6 percent.107

Horse Chestnut

Horse chestnut (Aesculus hippocastanum) is used in Western herbal medicine to treat diseases of the venous system. In Germany, preparations of horse chestnut are approved to treat diseases such as thrombophlebitis, varicose veins, and many types of edema. Aesculus extracts are the second most prescribed herbal monoprepa-ration in Germany, with annual retail sales of 103 million (U.S. dollars).79 In Chinese herbal medicine, the seed of a related plant, A. chinensis, is used to treat malnutrition and other digestive difficulties at a dose of 3 to 9 grams in decoction. Japanese herbal medicine prescribes the seed of A. turbinata, another related plant, to treat digestive difficulties and promote absorption.80

Conclusion

In the past decade, nutrition research has undergone an important shift in focus from epidemiology and physiology to molecular biology and genetics. This is a result of a growing realization that the effects of nutrition on health and disease cannot be understood without a profound understanding of how nutrients act at the molecular level micronutrients and macronutrients can be potent dietary signals that influence the metabolic programming of cells and have an important role in the control of homeostasis and or disease (28,240). Phytoestrogens are plant-derived molecules with estrogen-like action. Numerous reports exist on the potential beneficial role of nutritional phytoestrogens in human health (cancer chemoprevention, relief of postmenopausal symptoms, osteoporosis amelioration) (13-15,18-20). Herbal extracts are frequently used in traditional Chinese medicine for the treatment of hormonal disturbances or as health benefiting supplements (19). Often these preparations are...

Asia and Australia

The concept of neurasthenia or shenjing shuairuo (nerve weakness), as translated by the Chinese, was not an entirely alien idea. The symptoms associated with neurasthenia (fatigue, loss of memory, poor attention span, headache, tension, insomnia, and all varieties of vague pains) are similar to those in patients suffering from a deficiency in qi (vital essence), i.e. weakness of the kidney, spleen, or heart in traditional Chinese medicine. In addition, the theory of nerve weakness and depletion of nervous energy as causes of neurasthenia is congruent with the traditional Chinese medicine concept of organ weakness and yin-yang deficiency. Thus in no time at all neurasthenia was incorporated into the body of the practice of traditional Chinese medicine and the vocabulary of the lay public. Doctors in Malaysia, Singapore, India, Pakistan, Burma, and Sri Lanka are mostly trained in the British tradition. After the First World War neurasthenia lost its popularity in Britain. Standard...

Traditional Chinese Medicine

Traditional Chinese Medicine

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