Several prognostic factors have been advanced as indicators of poor outcome: stage greater than IE, diffuse large cell lymphoma histology, rapid clinical growth, abundant apoptosis, vascular invasion, high mitotic rate, perithyroidal extension and compressive clinical symptoms (36). The most important prognostic factor, however, is stage and this generally is in concert with the histological appearance, with MZBL of MALT-type being a low-grade lesion that is low stage with a very good prognosis and long survival.
Therapy is usually in the form of debulking surgery or combined adjuvant chemotherapy.
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